Ybor City is about the rise of unionism and the healing of racial divides within an American community. The musical is set in the town of Tampa Florida in 1918. When Rafael comes to town to read newspapers for the factory workers, he falls for Teresa, the sister of union organizer Catalino. Romance blossoms, tensions rise, and when Catalino stands up for worker rights, violence erupts. The community struggles to unite against an abusive factory owner and collectively form a multi-racial union.